Varaico: Literature-Extracted Genetic Variants

Gene:MAP2K2
Variant:p.S127L

MAP2K2

741 papers

RefSeq Summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transdu...

Pfam Domains

Pkinaseaa 72–369UCSCProtein kinase domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase 2

HGNC Previous Symbol

PRKMK2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
5 papers
NM_030662.4
p.S127L
c.380C>T
Surrounding Variants
1 paper
NM_030662.4
p.S127W
c.380C>G
1 paper
NM_030662.4
p.S127_P128ins1
c.381_382insATC
4 papers
NM_030662.4
p.P128S
c.382C>T
8 papers
NM_030662.4
p.P128L
c.383C>T
5 papers
NM_030662.4
p.P128R
c.383C>G
11 papers
NM_030662.4
p.P128Q
c.383C>A
8 papers
NM_030662.4
p.N126D
c.376A>G
1 paper
NM_030662.4
p.N126H
c.376A>C
2 papers
NM_030662.4
p.Y129H
c.385T>C
16 papers
NM_030662.4
p.C125S
c.374G>C
16 papers
NM_030662.4
p.C125S
c.373T>A
1 paper
NM_030662.4
p.E124delFs
c.371_372delTT
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."