Varaico: Literature-Extracted Genetic Variants

Gene:MAP2K5
Variant:p.K22N

MAP2K5

92 papers

RefSeq Summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself...

Pfam Domains

PB1aa 18–97UCSCPB1 domain
Pkinaseaa 166–419UCSCProtein kinase domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase 5

HGNC Previous Symbol

PRKMK5

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_145160.3
p.K22N
c.66G>T
Surrounding Variants
1 paper
NM_145160.3
p.K22N
c.66G>C
1 paper
NM_145160.3
p.K22R
c.65A>G
1 paper
NM_145160.3
p.L2L
c.6G>T
1 paper
NM_145160.3
p.G49delFs
c.145_146delGG
1 paper
NM_145160.3
p.E54Q
c.160G>C
1 paper
NM_145160.3
p.E61D
c.183A>T
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."