mitogen-activated protein kinase kinase 5

PRKMK5

MEK5

MAPKK5

HsT17454

dual specificity mitogen-activated protein kinase kinase 5

MAPK/ERK kinase 5

MAP kinase kinase 5

Dual specificity mitogen-activated protein kinase kinase 5

MAPKK 5

MEK 5

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011].

Varaico: Literature-Extracted Genetic Variants

MAP2K5

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol