Varaico: Literature-Extracted Genetic Variants

Gene:MAP2K5
Variant:p.R107S

MAP2K5

92 papers

RefSeq Summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself...

Pfam Domains

PB1aa 18–97UCSCPB1 domain
Pkinaseaa 166–419UCSCProtein kinase domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase 5

HGNC Previous Symbol

PRKMK5

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
7 papers
NM_145160.3
p.R107S
c.321A>T
Surrounding Variants
1 paper
NM_145160.3
p.A108V
c.323C>T
1 paper
NM_145160.3
p.I117K
c.350T>A
1 paper
NM_145160.3
p.G119D
c.356G>A
1 paper
NM_145160.3
p.S133G
c.397A>G
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."