Varaico: Literature-Extracted Genetic Variants

Gene:MAP2K5
Variant:p.W340C

MAP2K5

92 papers

RefSeq Summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself...

Pfam Domains

PB1aa 18–97UCSCPB1 domain
Pkinaseaa 166–419UCSCProtein kinase domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase 5

HGNC Previous Symbol

PRKMK5

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_145160.3
p.W340C
c.1020G>C
Surrounding Variants
1 paper
NM_145160.3
p.W340C
c.1020G>T
1 paper
NM_145160.3
p.S345F
c.1034C>T
2 papers
NM_145160.3
p.E348_L349Splc
c.1044+4C>T
9 papers
NM_145160.3
p.A321T
c.961G>A
1 paper
NM_145160.3
p.N320H
c.958A>C
1 paper
NM_145160.3
p.T315M
c.944C>T
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."