mitogen-activated protein kinase kinase 6

PRKMK6

MEK6

MKK6

SAPKK3

MAPKK6

CRCMSL

protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)

Colorectal Cancer Metastasis-Suppressed LncRNA

Dual specificity mitogen-activated protein kinase kinase 6

MAPK/ERK kinase 6

Stress-activated protein kinase kinase 3

MAP kinase kinase 6

MAPKK 6

MEK 6

SAPK kinase 3

SAPKK-3

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008].

Varaico: Literature-Extracted Genetic Variants

MAP2K6

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol