Varaico: Literature-Extracted Genetic Variants

MAP3K1

899 papers

RefSeq Summary

The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded...

Pfam Domains

SWIMaa 338–366UCSCSWIM zinc finger

TOG_MAP3K1aa 552–812UCSCMitogen-activated protein kinase kinase kinase 1, TOG domain

Pkinaseaa 1243–1508UCSCProtein kinase domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 1

HGNC Previous Symbol

MEKK1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_005921.2

p.P153L

c.458C>T

Surrounding Variants

1 paper

NM_005921.2

p.E152K

c.454G>A

1 paper

NM_005921.2

p.A151A

c.453C>G

1 paper

NM_005921.2

p.P149P

c.447C>T

4 papers

NM_005921.2

p.A157T

c.469G>A

2 papers

NM_005921.2

p.A157V

c.470C>T

1 paper

NM_005921.2

p.A148A

c.444G>A

1 paper

NM_005921.2

p.P159delFs

c.477delC

1 paper

NM_005921.2

p.A148V

c.443C>T

2 papers

NM_005921.2

p.A148T

c.442G>A

2 papers

NM_005921.2

p.P159L

c.476C>T

1 paper

NM_005921.2

p.A160fs

c.478_479fs

1 paper

NM_005921.2

p.A160fs

c.478_479fs