Varaico: Literature-Extracted Genetic Variants

Gene:MAP3K10

MAP3K10

110 papers

RefSeq Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thu...

Pfam Domains

SH3_9aa 23–77UCSCVariant SH3 domain
PK_Tyr_Ser-Thraa 98–357UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 10

HGNC Previous Symbol

MLK2

Papers
RefSeq ID
Protein change
DNA change
1–12 of 127 variants
3 papers
NM_002446.4
p.R850H
c.2549G>A
2 papers
NM_002446.4
p.G107E
c.320G>A
2 papers
NM_002446.4
p.E132Q
c.394G>C
2 papers
NM_002446.4
p.G524_S528del0
c.1571_1582del12
2 papers
NM_002446.4
p.P651T
c.1951C>A
2 papers
NM_002446.4
p.G677S
c.2029G>A
2 papers
NM_002446.4
p.S775C
c.2324C>G
2 papers
NM_002446.4
p.T784P
c.2350A>C
2 papers
NM_002446.4
p.R823C
c.2467C>T
2 papers
NM_002446.4
p.F865F
c.2595C>T
1 paper
NM_002446.4
p.E5del1
c.13_14delGAG
1 paper
NM_002446.4
p.E11*
c.31G>T
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."