Varaico: Literature-Extracted Genetic Variants

Gene:MAP3K10
Variant:p.E132K

MAP3K10

110 papers

RefSeq Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thu...

Pfam Domains

SH3_9aa 23–77UCSCVariant SH3 domain
PK_Tyr_Ser-Thraa 98–357UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 10

HGNC Previous Symbol

MLK2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002446.4
p.E132K
c.394G>A
Surrounding Variants
2 papers
NM_002446.4
p.E132Q
c.394G>C
1 paper
NM_002446.4
p.T138A
c.412A>G
1 paper
NM_002446.4
p.K125M
c.374A>T
1 paper
NM_002446.4
p.K125E
c.373A>G
1 paper
NM_002446.4
p.A139P
c.415G>C
1 paper
NM_002446.4
p.Q141K
c.421C>A
1 paper
NM_002446.4
p.E120K
c.358G>A
1 paper
NM_002446.4
p.R114Q
c.341G>A
1 paper
NM_002446.4
p.G108C
c.322G>T
2 papers
NM_002446.4
p.G107E
c.320G>A
1 paper
NM_002446.4
p.V106Fs
c.317delinsTGFs
1 paper
NM_002446.4
p.Q99L
c.296A>T
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."