Varaico: Literature-Extracted Genetic Variants

Gene:MAP3K10
Variant:p.G524_S528del0

MAP3K10

110 papers

RefSeq Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thu...

Pfam Domains

SH3_9aa 23–77UCSCVariant SH3 domain
PK_Tyr_Ser-Thraa 98–357UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 10

HGNC Previous Symbol

MLK2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_002446.4
p.G524_S528del0
c.1571_1582del12
Surrounding Variants
1 paper
NM_002446.4
p.G524_S528del5
c.1570_1583del15
1 paper
NM_002446.4
p.W538*
c.1613G>A
1 paper
NM_002446.4
p.W538*
c.1614G>A
1 paper
NM_002446.4
p.G541D
c.1622G>A
1 paper
NM_002446.4
p.G622S
c.1864G>A
1 paper
NM_002446.4
p.L640L
c.1918C>T
1 paper
NM_002446.4
p.P641S
c.1921C>T
1 paper
NM_002446.4
p.A648T
c.1942G>A
1 paper
NM_002446.4
p.R649Q
c.1946G>A
2 papers
NM_002446.4
p.P651T
c.1951C>A
1 paper
NM_002446.4
p.S657S
c.1971C>T
1 paper
NM_002446.4
p.A658V
c.1973C>T
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