Varaico: Literature-Extracted Genetic Variants

Gene:MAP3K10
Variant:p.R668L

MAP3K10

110 papers

RefSeq Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thu...

Pfam Domains

SH3_9aa 23–77UCSCVariant SH3 domain
PK_Tyr_Ser-Thraa 98–357UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 10

HGNC Previous Symbol

MLK2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002446.4
p.R668L
c.2003G>T
Surrounding Variants
2 papers
NM_002446.4
p.G677S
c.2029G>A
1 paper
NM_002446.4
p.A658V
c.1973C>T
1 paper
NM_002446.4
p.S657S
c.1971C>T
1 paper
NM_002446.4
p.A684V
c.2051C>T
1 paper
NM_002446.4
p.G686delFs
c.2057delG
2 papers
NM_002446.4
p.P651T
c.1951C>A
1 paper
NM_002446.4
p.R649Q
c.1946G>A
1 paper
NM_002446.4
p.A648T
c.1942G>A
1 paper
NM_002446.4
p.E693K
c.2077G>A
1 paper
NM_002446.4
p.P641S
c.1921C>T
1 paper
NM_002446.4
p.L640L
c.1918C>T
1 paper
NM_002446.4
p.W705C
c.2115G>C
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