Varaico: Literature-Extracted Genetic Variants

Gene:MAP3K10
Variant:p.R823C

MAP3K10

110 papers

RefSeq Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thu...

Pfam Domains

SH3_9aa 23–77UCSCVariant SH3 domain
PK_Tyr_Ser-Thraa 98–357UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 10

HGNC Previous Symbol

MLK2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_002446.4
p.R823C
c.2467C>T
Surrounding Variants
1 paper
NM_002446.4
p.R826W
c.2476C>T
1 paper
NM_002446.4
p.R827Q
c.2480G>A
1 paper
NM_002446.4
p.P812S
c.2434C>T
1 paper
NM_002446.4
p.G838fs
c.2512_2513fs
1 paper
NM_002446.4
p.P840L
c.2519C>T
1 paper
NM_002446.4
p.L794P
c.2381T>C
2 papers
NM_002446.4
p.T784P
c.2350A>C
1 paper
NM_002446.4
p.A782P
c.2344G>C
1 paper
NM_002446.4
p.A782del1
c.2344_2345delGCG
1 paper
NM_002446.4
p.P780T
c.2338C>A
1 paper
NM_002446.4
p.S779P
c.2335T>C
2 papers
NM_002446.4
p.S775C
c.2324C>G
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