Varaico: Literature-Extracted Genetic Variants

Gene:MAP3K10
Variant:p.R850H

MAP3K10

110 papers

RefSeq Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thu...

Pfam Domains

SH3_9aa 23–77UCSCVariant SH3 domain
PK_Tyr_Ser-Thraa 98–357UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 10

HGNC Previous Symbol

MLK2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
3 papers
NM_002446.4
p.R850H
c.2549G>A
Surrounding Variants
1 paper
NM_002446.4
p.P849L
c.2546C>T
1 paper
NM_002446.4
p.L853fs
c.2557_2558fs
1 paper
NM_002446.4
p.R857P
c.2570G>C
2 papers
NM_002446.4
p.F865F
c.2595C>T
1 paper
NM_002446.4
p.R869H
c.2606G>A
1 paper
NM_002446.4
p.P889P
c.2667G>A
1 paper
NM_002446.4
p.A891V
c.2672C>T
1 paper
NM_002446.4
p.P929S
c.2785C>T
1 paper
NM_002446.4
p.D942N
c.2824G>A
1 paper
NM_002446.4
p.G949R
c.2845G>A
1 paper
NM_002446.4
p.G949R
c.2845G>C
1 paper
NM_002446.4
p.P840L
c.2519C>T
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