Varaico: Literature-Extracted Genetic Variants

MAP3K11

124 papers

RefSeq Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK k...

Pfam Domains

SH3_9aa 48–101UCSCVariant SH3 domain

PK_Tyr_Ser-Thraa 117–376UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 11

HGNC Previous Symbols

MLK3; PTK1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002419.4

p.T804A

c.2410A>G

Surrounding Variants

2 papers

NM_002419.4

p.R799C

c.2395C>T

1 paper

NM_002419.4

p.P794S

c.2380C>T

1 paper

NM_002419.4

p.A818V

c.2453C>T

1 paper

NM_002419.4

p.Q826fs

c.2476_2477fs

1 paper

NM_002419.4

p.Q826delFs

c.2476delG

1 paper

NM_002419.4

p.P840L

c.2519C>T

1 paper

NM_002419.4

p.P843S

c.2527C>T

2 papers

NM_002419.4

p.R757H

c.2270G>A

1 paper

NM_002419.4

p.R757C

c.2269C>T

1 paper

NM_002419.4

p.P753P

c.2259A>T

2 papers

NM_002419.4

p.R747C

c.2239C>T

1 paper

NM_002419.4

p.P743L

c.2228C>T