Varaico: Literature-Extracted Genetic Variants

MAP3K11

124 papers

RefSeq Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK k...

Pfam Domains

SH3_9aa 48–101UCSCVariant SH3 domain

PK_Tyr_Ser-Thraa 117–376UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 11

HGNC Previous Symbols

MLK3; PTK1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_002419.4

p.T680P

c.2038A>C

Surrounding Variants

1 paper

NM_002419.4

p.T680M

c.2039C>T

2 papers

NM_002419.4

p.A684T

c.2050G>A

2 papers

NM_002419.4

p.A684V

c.2051C>T

1 paper

NM_002419.4

p.A684A

c.2052G>A

1 paper

NM_002419.4

p.R671C

c.2011C>T

1 paper

NM_002419.4

p.P690L

c.2069C>T

1 paper

NM_002419.4

p.P664A

c.1990C>G

1 paper

NM_002419.4

p.Q662*

c.1984C>T

1 paper

NM_002419.4

p.P706L

c.2117C>T

1 paper

NM_002419.4

p.P706P

c.2118G>A

1 paper

NM_002419.4

p.A644V

c.1931C>T

1 paper

NM_002419.4

p.R643insFs

c.1928_1929insG