Varaico: Literature-Extracted Genetic Variants

MAP3K11

124 papers

RefSeq Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK k...

Pfam Domains

SH3_9aa 48–101UCSCVariant SH3 domain

PK_Tyr_Ser-Thraa 117–376UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 11

HGNC Previous Symbols

MLK3; PTK1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002419.4

p.D593E

c.1779T>A

Surrounding Variants

1 paper

NM_002419.4

p.A588T

c.1762G>A

1 paper

NM_002419.4

p.P607fs

c.1819_1820fs

2 papers

NM_002419.4

p.P606delFs

c.1816delG

2 papers

NM_002419.4

p.S570F

c.1709C>T

1 paper

NM_002419.4

p.P549L

c.1646C>T

1 paper

NM_002419.4

p.W544R

c.1630T>C

1 paper

NM_002419.4

p.W544R

c.1630T>A

1 paper

NM_002419.4

p.R531*

c.1591C>T

1 paper

NM_002419.4

p.N515S

c.1544A>G

1 paper

NM_002419.4

p.R512Q

c.1535G>A

1 paper

NM_002419.4

p.R512W

c.1534C>T

1 paper

NM_002419.4

p.D511N

c.1531G>A