Varaico: Literature-Extracted Genetic Variants

MAP3K11

124 papers

RefSeq Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK k...

Pfam Domains

SH3_9aa 48–101UCSCVariant SH3 domain

PK_Tyr_Ser-Thraa 117–376UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 11

HGNC Previous Symbols

MLK3; PTK1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002419.4

p.R531*

c.1591C>T

Surrounding Variants

1 paper

NM_002419.4

p.N515S

c.1544A>G

1 paper

NM_002419.4

p.R512Q

c.1535G>A

1 paper

NM_002419.4

p.R512W

c.1534C>T

1 paper

NM_002419.4

p.D511N

c.1531G>A

1 paper

NM_002419.4

p.R473H

c.1418G>A

1 paper

NM_002419.4

p.W544R

c.1630T>C

1 paper

NM_002419.4

p.W544R

c.1630T>A

2 papers

NM_002419.4

p.P469A

c.1405C>G

1 paper

NM_002419.4

p.P549L

c.1646C>T

1 paper

NM_002419.4

p.T458M

c.1373C>T

1 paper

NM_002419.4

p.E454_R455delFs

c.1361_1364del4

2 papers

NM_002419.4

p.S570F

c.1709C>T