Varaico: Literature-Extracted Genetic Variants

MAP3K11

124 papers

RefSeq Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK k...

Pfam Domains

SH3_9aa 48–101UCSCVariant SH3 domain

PK_Tyr_Ser-Thraa 117–376UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 11

HGNC Previous Symbols

MLK3; PTK1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002419.4

p.T277A

c.829A>G

Surrounding Variants

1 paper

NM_002419.4

p.T278A

c.832A>G

1 paper

NM_002419.4

p.F268L

c.804T>A

1 paper

NM_002419.4

p.Y286C

c.857A>G

1 paper

NM_002419.4

p.D267N

c.799G>A

1 paper

NM_002419.4

p.T266T

c.798C>T

1 paper

NM_002419.4

p.A296T

c.886G>A

2 papers

NM_002419.4

p.P252H

c.755C>A

1 paper

NM_002419.4

p.E314K

c.940G>A

1 paper

NM_002419.4

p.A352T

c.1054G>A

1 paper

NM_002419.4

p.A356V

c.1067C>T

1 paper

NM_002419.4

p.D357Splc

c.1069+10C>T

1 paper

NM_002419.4

p.C358Y

c.1073G>A