Varaico: Literature-Extracted Genetic Variants

MAP3K11

124 papers

RefSeq Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK k...

Pfam Domains

SH3_9aa 48–101UCSCVariant SH3 domain

PK_Tyr_Ser-Thraa 117–376UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 11

HGNC Previous Symbols

MLK3; PTK1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002419.4

p.L171Q

c.512T>A

Surrounding Variants

2 papers

NM_002419.4

p.I176V

c.526A>G

1 paper

NM_002419.4

p.I177T

c.530T>C

1 paper

NM_002419.4

p.Q163Q

c.489G>A

1 paper

NM_002419.4

p.V161I

c.481G>A

1 paper

NM_002419.4

p.T157K

c.470C>A

1 paper

NM_002419.4

p.V156L

c.466G>T

1 paper

NM_002419.4

p.V156L

c.466G>C

1 paper

NM_002419.4

p.D151V

c.452A>T

1 paper

NM_002419.4

p.A196A

c.588A>T

1 paper

NM_002419.4

p.K144M

c.431A>T

3 papers

NM_002419.4

p.K144R

c.431A>G

1 paper

NM_002419.4

p.E139Q

c.415G>C