Varaico: Literature-Extracted Genetic Variants

MAP3K15

101 papers

RefSeq Summary

The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MA...

Pfam Domains

DRHyd-ASKaa 86–121UCSCDeoxyribohydrolase (DRHyd) domain of the ASK signalosome

MAP3K_TRAF_bdaa 136–515UCSCMAP3K TRAFs-binding domain

ASK_PHaa 525–624UCSCASK kinase PH domain

Pkinaseaa 654–908UCSCProtein kinase domain

HisK-N-likeaa 1003–1134UCSCHisK-N-like globin domain of the ASK signalosome

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 15

HGNC Alias Symbols

bA723P2.3; FLJ16518; ASK3

Papers

RefSeq ID

Protein change

DNA change

1–12 of 167 variants

5 papers

NM_001001671.4

p.R1136*

c.3406C>T

3 papers

NM_001001671.4

p.R494C

c.1480C>T

2 papers

NM_001001671.4

p.S199N

c.596G>A

2 papers

NM_001001671.4

p.V455I

c.1363G>A

2 papers

NM_001001671.4

p.Y645*

c.1935T>G

2 papers

NM_001001671.4

p.Y645*

c.1935T>A

2 papers

NM_001001671.4

p.K751T

c.2252A>C

2 papers

NM_001001671.4

p.G838S

c.2512G>A

2 papers

NM_001001671.4

p.N1029H

c.3085A>C

2 papers

NM_001001671.4

p.R1122*

c.3364C>T

2 papers

NM_001001671.4

p.Q1251E

c.3751C>G

1 paper

NM_001001671.4

p.A10T

c.28G>A