Varaico: Literature-Extracted Genetic Variants

MAP3K15

101 papers

RefSeq Summary

The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MA...

Pfam Domains

DRHyd-ASKaa 86–121UCSCDeoxyribohydrolase (DRHyd) domain of the ASK signalosome

MAP3K_TRAF_bdaa 136–515UCSCMAP3K TRAFs-binding domain

ASK_PHaa 525–624UCSCASK kinase PH domain

Pkinaseaa 654–908UCSCProtein kinase domain

HisK-N-likeaa 1003–1134UCSCHisK-N-like globin domain of the ASK signalosome

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 15

HGNC Alias Symbols

bA723P2.3; FLJ16518; ASK3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001001671.4

p.P748P

c.2244G>A

Surrounding Variants

1 paper

NM_001001671.4

p.P748L

c.2243C>T

2 papers

NM_001001671.4

p.K751T

c.2252A>C

1 paper

NM_001001671.4

p.W742*

c.2226G>A

1 paper

NM_001001671.4

p.W742*

c.2225G>A

1 paper

NM_001001671.4

p.K741fs

c.2221_2222fs

1 paper

NM_001001671.4

p.K762E

c.2284A>G

1 paper

NM_001001671.4

p.Y784*

c.2352C>G

1 paper

NM_001001671.4

p.Y784*

c.2352C>A

1 paper

NM_001001671.4

p.G786R

c.2356G>C

1 paper

NM_001001671.4

p.G786R

c.2356G>A

1 paper

NM_001001671.4

p.K789*

c.2365A>T

1 paper

NM_001001671.4

p.S796*

c.2387C>A