Varaico: Literature-Extracted Genetic Variants

MAP3K15

101 papers

RefSeq Summary

The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MA...

Pfam Domains

DRHyd-ASKaa 86–121UCSCDeoxyribohydrolase (DRHyd) domain of the ASK signalosome

MAP3K_TRAF_bdaa 136–515UCSCMAP3K TRAFs-binding domain

ASK_PHaa 525–624UCSCASK kinase PH domain

Pkinaseaa 654–908UCSCProtein kinase domain

HisK-N-likeaa 1003–1134UCSCHisK-N-like globin domain of the ASK signalosome

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 15

HGNC Alias Symbols

bA723P2.3; FLJ16518; ASK3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001001671.4

p.Y243D

c.727T>G

Surrounding Variants

1 paper

NM_001001671.4

p.Y242*

c.726T>G

1 paper

NM_001001671.4

p.Y242*

c.726T>A

1 paper

NM_001001671.4

p.K253R

c.758A>G

1 paper

NM_001001671.4

p.D275D

c.825T>C

1 paper

NM_001001671.4

p.E278A

c.833A>C

1 paper

NM_001001671.4

p.D283A

c.848A>C

1 paper

NM_001001671.4

p.L290L

c.868C>T

1 paper

NM_001001671.4

p.L304P

c.911T>C

1 paper

NM_001001671.4

p.A317fs

c.949_950fs

1 paper

NM_001001671.4

p.H320L

c.959A>T

1 paper

NM_001001671.4

p.T238T

c.714C>T

1 paper

NM_001001671.4

p.D234E

c.702C>G