Varaico: Literature-Extracted Genetic Variants

MAP3K15

101 papers

RefSeq Summary

The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MA...

Pfam Domains

DRHyd-ASKaa 86–121UCSCDeoxyribohydrolase (DRHyd) domain of the ASK signalosome

MAP3K_TRAF_bdaa 136–515UCSCMAP3K TRAFs-binding domain

ASK_PHaa 525–624UCSCASK kinase PH domain

Pkinaseaa 654–908UCSCProtein kinase domain

HisK-N-likeaa 1003–1134UCSCHisK-N-like globin domain of the ASK signalosome

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 15

HGNC Alias Symbols

bA723P2.3; FLJ16518; ASK3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001001671.4

p.T238T

c.714C>T

Surrounding Variants

1 paper

NM_001001671.4

p.D234E

c.702C>G

1 paper

NM_001001671.4

p.D234E

c.702C>A

1 paper

NM_001001671.4

p.I229F

c.685A>T

1 paper

NM_001001671.4

p.P219P

c.657G>A

1 paper

NM_001001671.4

p.Q210*

c.628C>T

2 papers

NM_001001671.4

p.S199N

c.596G>A

1 paper

NM_001001671.4

p.C196*

c.588C>A

1 paper

NM_001001671.4

p.A192T

c.574G>A

1 paper

NM_001001671.4

p.I184T

c.551T>C

1 paper

NM_001001671.4

p.N180T

c.539A>C

1 paper

NM_001001671.4

p.Y242*

c.726T>G

1 paper

NM_001001671.4

p.Y242*

c.726T>A