Varaico: Literature-Extracted Genetic Variants

MAP3K15

101 papers

RefSeq Summary

The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MA...

Pfam Domains

DRHyd-ASKaa 86–121UCSCDeoxyribohydrolase (DRHyd) domain of the ASK signalosome

MAP3K_TRAF_bdaa 136–515UCSCMAP3K TRAFs-binding domain

ASK_PHaa 525–624UCSCASK kinase PH domain

Pkinaseaa 654–908UCSCProtein kinase domain

HisK-N-likeaa 1003–1134UCSCHisK-N-like globin domain of the ASK signalosome

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 15

HGNC Alias Symbols

bA723P2.3; FLJ16518; ASK3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001001671.4

p.V28G

c.83T>G

Surrounding Variants

1 paper

NM_001001671.4

p.P26del1

c.76_77delCGG

1 paper

NM_001001671.4

p.A35fs

c.103_104fs

1 paper

NM_001001671.4

p.A40V

c.119C>T

1 paper

NM_001001671.4

p.G14E

c.41G>A

1 paper

NM_001001671.4

p.L13F

c.37C>T

1 paper

NM_001001671.4

p.A10T

c.28G>A

1 paper

NM_001001671.4

p.E52D

c.156G>T

1 paper

NM_001001671.4

p.E52D

c.156G>C

1 paper

NM_001001671.4

p.G55A

c.164G>C

1 paper

NM_001001671.4

p.V64V

c.192A>T

1 paper

NM_001001671.4

p.G77fs

c.229_230fs

1 paper

NM_001001671.4

p.A90delFs

c.268delC