Varaico: Literature-Extracted Genetic Variants

MAP3K4

247 papers

RefSeq Summary

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific M...

Pfam Domains

MEKK4_Naa 51–1269UCSCMEKK4 N-terminal

MEKK4_Naa 1169–1215UCSCMEKK4 N-terminal

Pkinaseaa 1343–1601UCSCProtein kinase domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 4

HGNC Previous Symbol

MEKK4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_005922.4

p.R157_K158insFs

c.471_472insA

Surrounding Variants

2 papers

NM_005922.4

p.N160delFs

c.479delA

1 paper

NM_005922.4

p.K158fs

c.472_473fs

8 papers

NM_005922.4

p.R157H

c.470G>A

1 paper

NM_005922.4

p.R157Fs

c.470_471delinsATAFs

1 paper

NM_005922.4

p.R157_K158Fs

c.470_472delinsATFs

1 paper

NM_005922.4

p.R157G

c.469C>G

2 papers

NM_005922.4

p.R157fs

c.469_470fs

2 papers

NM_005922.4

p.N160fs

c.478_479fs

2 papers

NM_005922.4

p.N160fs

c.478_479fs

1 paper

NM_005922.4

p.R155C

c.463C>T

1 paper

NM_005922.4

p.E154K

c.460G>A

1 paper

NM_005922.4

p.T152I

c.455C>T