Varaico: Literature-Extracted Genetic Variants

MAP3K4

247 papers

RefSeq Summary

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific M...

Pfam Domains

MEKK4_Naa 51–1269UCSCMEKK4 N-terminal

MEKK4_Naa 1169–1215UCSCMEKK4 N-terminal

Pkinaseaa 1343–1601UCSCProtein kinase domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 4

HGNC Previous Symbol

MEKK4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_005922.4

p.I179V

c.535A>G

Surrounding Variants

1 paper

NM_005922.4

p.P175delFs

c.525delA

1 paper

NM_005922.4

p.P175fs

c.523_524fs

1 paper

NM_005922.4

p.D183Y

c.547G>T

1 paper

NM_005922.4

p.S173A

c.517T>G

1 paper

NM_005922.4

p.K186R

c.557A>G

4 papers

NM_005922.4

p.N195H

c.583A>C

2 papers

NM_005922.4

p.N160fs

c.478_479fs

2 papers

NM_005922.4

p.N160fs

c.478_479fs

1 paper

NM_005922.4

p.P199S

c.595C>T

1 paper

NM_005922.4

p.K158fs

c.472_473fs

2 papers

NM_005922.4

p.R157_K158insFs

c.471_472insA

2 papers

NM_005922.4

p.N160delFs

c.479delA