Varaico: Literature-Extracted Genetic Variants

MAP3K4

247 papers

RefSeq Summary

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific M...

Pfam Domains

MEKK4_Naa 51–1269UCSCMEKK4 N-terminal

MEKK4_Naa 1169–1215UCSCMEKK4 N-terminal

Pkinaseaa 1343–1601UCSCProtein kinase domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 4

HGNC Previous Symbol

MEKK4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_005922.4

p.I206V

c.616A>G

Surrounding Variants

1 paper

NM_005922.4

p.A207G

c.620C>G

1 paper

NM_005922.4

p.M204I

c.612G>A

1 paper

NM_005922.4

p.M204I

c.612G>C

1 paper

NM_005922.4

p.M204I

c.612G>T

1 paper

NM_005922.4

p.R208K

c.623G>A

1 paper

NM_005922.4

p.Q212*

c.634C>T

1 paper

NM_005922.4

p.P199S

c.595C>T

1 paper

NM_005922.4

p.S214F

c.641C>T

1 paper

NM_005922.4

p.R215delFs

c.643_644delAG

4 papers

NM_005922.4

p.N195H

c.583A>C

1 paper

NM_005922.4

p.R222H

c.665G>A

1 paper

NM_005922.4

p.F225delFs

c.675delT