Varaico: Literature-Extracted Genetic Variants

MAP3K4

247 papers

RefSeq Summary

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific M...

Pfam Domains

MEKK4_Naa 51–1269UCSCMEKK4 N-terminal

MEKK4_Naa 1169–1215UCSCMEKK4 N-terminal

Pkinaseaa 1343–1601UCSCProtein kinase domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 4

HGNC Previous Symbol

MEKK4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005922.4

p.H272L

c.815A>T

Surrounding Variants

1 paper

NM_005922.4

p.R275Q

c.824G>A

1 paper

NM_005922.4

p.D279N

c.835G>A

1 paper

NM_005922.4

p.F282S

c.845T>C

2 papers

NM_005922.4

p.E262K

c.784G>A

1 paper

NM_005922.4

p.R288H

c.863G>A

1 paper

NM_005922.4

p.G254S

c.760G>A

1 paper

NM_005922.4

p.D293N

c.877G>A

2 papers

NM_005922.4

p.I294T

c.881T>C

1 paper

NM_005922.4

p.D243N

c.727G>A

1 paper

NM_005922.4

p.S307N

c.920G>A

1 paper

NM_005922.4

p.V311L

c.931G>C

1 paper

NM_005922.4

p.L233I

c.697C>A