Varaico: Literature-Extracted Genetic Variants

MAP3K4

247 papers

RefSeq Summary

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific M...

Pfam Domains

MEKK4_Naa 51–1269UCSCMEKK4 N-terminal

MEKK4_Naa 1169–1215UCSCMEKK4 N-terminal

Pkinaseaa 1343–1601UCSCProtein kinase domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 4

HGNC Previous Symbol

MEKK4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005922.4

p.K333R

c.998A>G

Surrounding Variants

1 paper

NM_005922.4

p.V335I

c.1003G>A

1 paper

NM_005922.4

p.G331V

c.992G>T

1 paper

NM_005922.4

p.T329I

c.986C>T

1 paper

NM_005922.4

p.A328S

c.982G>T

1 paper

NM_005922.4

p.Q325R

c.974A>G

1 paper

NM_005922.4

p.Q345H

c.1035A>T

1 paper

NM_005922.4

p.R346H

c.1037G>A

1 paper

NM_005922.4

p.F317L

c.951T>A

1 paper

NM_005922.4

p.F317L

c.951T>G

1 paper

NM_005922.4

p.V349A

c.1046T>C

1 paper

NM_005922.4

p.F317L

c.949T>C

1 paper

NM_005922.4

p.G316V

c.947G>T