Varaico: Literature-Extracted Genetic Variants

MAP3K4

247 papers

RefSeq Summary

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific M...

Pfam Domains

MEKK4_Naa 51–1269UCSCMEKK4 N-terminal

MEKK4_Naa 1169–1215UCSCMEKK4 N-terminal

Pkinaseaa 1343–1601UCSCProtein kinase domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 4

HGNC Previous Symbol

MEKK4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005922.4

p.V349A

c.1046T>C

Surrounding Variants

1 paper

NM_005922.4

p.E352Q

c.1054G>C

1 paper

NM_005922.4

p.R346H

c.1037G>A

1 paper

NM_005922.4

p.Q345H

c.1035A>T

1 paper

NM_005922.4

p.R356G

c.1066C>G

1 paper

NM_005922.4

p.R356W

c.1066C>T

1 paper

NM_005922.4

p.M358I

c.1074G>A

1 paper

NM_005922.4

p.M358I

c.1074G>C

1 paper

NM_005922.4

p.M358I

c.1074G>T

2 papers

NM_005922.4

p.E362*

c.1084G>T

1 paper

NM_005922.4

p.V335I

c.1003G>A

1 paper

NM_005922.4

p.K333R

c.998A>G

1 paper

NM_005922.4

p.G331V

c.992G>T