Varaico: Literature-Extracted Genetic Variants

MAP3K4

247 papers

RefSeq Summary

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific M...

Pfam Domains

MEKK4_Naa 51–1269UCSCMEKK4 N-terminal

MEKK4_Naa 1169–1215UCSCMEKK4 N-terminal

Pkinaseaa 1343–1601UCSCProtein kinase domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 4

HGNC Previous Symbol

MEKK4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

6 papers

NM_005922.4

p.W396delFs

c.1186_1187delTG

Surrounding Variants

1 paper

NM_005922.4

p.W396delFs

c.1186delT

4 papers

NM_005922.4

p.L397delFs

c.1189_1190delTT

1 paper

NM_005922.4

p.A392E

c.1175C>A

1 paper

NM_005922.4

p.T400delFs

c.1199_1200delCA

1 paper

NM_005922.4

p.A383T

c.1147G>A

1 paper

NM_005922.4

p.G411D

c.1232G>A

1 paper

NM_005922.4

p.G411G

c.1233C>T

1 paper

NM_005922.4

p.L414V

c.1240T>G

1 paper

NM_005922.4

p.L414L

c.1242G>A

1 paper

NM_005922.4

p.Q372del1

c.1114_1116delCAG

1 paper

NM_005922.4

p.S420T

c.1258T>A

1 paper

NM_005922.4

p.P369S

c.1105C>T