Varaico: Literature-Extracted Genetic Variants

MAP3K4

247 papers

RefSeq Summary

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific M...

Pfam Domains

MEKK4_Naa 51–1269UCSCMEKK4 N-terminal

MEKK4_Naa 1169–1215UCSCMEKK4 N-terminal

Pkinaseaa 1343–1601UCSCProtein kinase domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 4

HGNC Previous Symbol

MEKK4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_005922.4

p.Q584H

c.1752G>T

Surrounding Variants

4 papers

NM_005922.4

p.Q584H

c.1752G>C

1 paper

NM_005922.4

p.E593K

c.1777G>A

1 paper

NM_005922.4

p.P576S

c.1726C>T

1 paper

NM_005922.4

p.K605R

c.1814A>G

1 paper

NM_005922.4

p.A606S

c.1816G>T

1 paper

NM_005922.4

p.S611L

c.1832C>T

1 paper

NM_005922.4

p.E613K

c.1837G>A

1 paper

NM_005922.4

p.P614S

c.1840C>T

1 paper

NM_005922.4

p.E629K

c.1885G>A

1 paper

NM_005922.4

p.R634K

c.1901G>A

1 paper

NM_005922.4

p.P643_S644del2

c.1927_1931del6

1 paper

NM_005922.4

p.P643_S644del1

c.1928_1930delCAT