Varaico: Literature-Extracted Genetic Variants

MAP3K4

247 papers

RefSeq Summary

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific M...

Pfam Domains

MEKK4_Naa 51–1269UCSCMEKK4 N-terminal

MEKK4_Naa 1169–1215UCSCMEKK4 N-terminal

Pkinaseaa 1343–1601UCSCProtein kinase domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 4

HGNC Previous Symbol

MEKK4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005922.4

p.A1183P

c.3547G>C

Surrounding Variants

1 paper

NM_005922.4

p.A1183V

c.3548C>T

4 papers

NM_005922.4

p.S1185_H1186del2

c.3553_3557del6

1 paper

NM_005922.4

p.S1185_S1188del0

c.3554_3562del9

4 papers

NM_005922.4

p.S1185_H1186del1

c.3554_3556delGCC

2 papers

NM_005922.4

p.H1186_G1187del2

c.3556_3560del6

1 paper

NM_005922.4

p.H1186del1

c.3556_3557delCAT

3 papers

NM_005922.4

p.H1186_G1187del1

c.3557_3559delATG

1 paper

NM_005922.4

p.S1178R

c.3534C>A

1 paper

NM_005922.4

p.S1178R

c.3534C>G

1 paper

NM_005922.4

p.S1178R

c.3532A>C

4 papers

NM_005922.4

p.P1189_A1190del2

c.3565_3569del6

1 paper

NM_005922.4

p.A1198_V1200ins1

c.3593_3598dup6