Varaico: Literature-Extracted Genetic Variants

MAP3K4

247 papers

RefSeq Summary

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific M...

Pfam Domains

MEKK4_Naa 51–1269UCSCMEKK4 N-terminal

MEKK4_Naa 1169–1215UCSCMEKK4 N-terminal

Pkinaseaa 1343–1601UCSCProtein kinase domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 4

HGNC Previous Symbol

MEKK4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_005922.4

p.P1189_A1190del2

c.3565_3569del6

Surrounding Variants

1 paper

NM_005922.4

p.A1198_V1200ins1

c.3593_3598dup6

1 paper

NM_005922.4

p.A1197_V1200ins1

c.3590_3598dup9

1 paper

NM_005922.4

p.P1189fs

c.3565_3566fs

23 papers

NM_005922.4

p.P1189_A1190del1

c.3566_3568delCTG

2 papers

NM_005922.4

p.A1197_A1199del0

c.3590_3595del6

1 paper

NM_005922.4

p.P1189_A1192del0

c.3566_3574del9

1 paper

NM_005922.4

p.A1194_V1200del0

c.3581_3598del18

3 papers

NM_005922.4

p.H1186_G1187del1

c.3557_3559delATG

1 paper

NM_005922.4

p.H1186del1

c.3556_3557delCAT

4 papers

NM_005922.4

p.S1185_H1186del1

c.3554_3556delGCC

2 papers

NM_005922.4

p.H1186_G1187del2

c.3556_3560del6

4 papers

NM_005922.4

p.S1185_H1186del2

c.3553_3557del6