Varaico: Literature-Extracted Genetic Variants

MAP3K4

247 papers

RefSeq Summary

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific M...

Pfam Domains

MEKK4_Naa 51–1269UCSCMEKK4 N-terminal

MEKK4_Naa 1169–1215UCSCMEKK4 N-terminal

Pkinaseaa 1343–1601UCSCProtein kinase domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 4

HGNC Previous Symbol

MEKK4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005922.4

p.S1289P

c.3865T>C

Surrounding Variants

1 paper

NM_005922.4

p.A1296S

c.3886G>T

1 paper

NM_005922.4

p.A1296D

c.3887C>A

2 papers

NM_005922.4

p.R1302*

c.3904C>T

1 paper

NM_005922.4

p.E1306Q

c.3916G>C

1 paper

NM_005922.4

p.R1308T

c.3923G>C

1 paper

NM_005922.4

p.C1322insFs

c.3965_3966ins40

1 paper

NM_005922.4

p.T1340T

c.4020C>T

2 papers

NM_005922.4

p.W1343R

c.4027T>A

2 papers

NM_005922.4

p.W1343R

c.4027T>C

1 paper

NM_005922.4

p.G1350Splc

c.4048+251C>G

1 paper

NM_005922.4

p.G1350Splc

c.4049-11A>G

1 paper

NM_005922.4

p.K1356*

c.4066A>T