Varaico: Literature-Extracted Genetic Variants

MAP3K4

247 papers

RefSeq Summary

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific M...

Pfam Domains

MEKK4_Naa 51–1269UCSCMEKK4 N-terminal

MEKK4_Naa 1169–1215UCSCMEKK4 N-terminal

Pkinaseaa 1343–1601UCSCProtein kinase domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 4

HGNC Previous Symbol

MEKK4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_005922.4

p.D1364Y

c.4090G>T

Surrounding Variants

10 papers

NM_005922.4

p.G1366R

c.4096G>A

10 papers

NM_005922.4

p.G1366R

c.4096G>C

1 paper

NM_005922.4

p.I1361M

c.4083C>G

1 paper

NM_005922.4

p.G1366E

c.4097G>A

1 paper

NM_005922.4

p.T1359delFs

c.4077delC

1 paper

NM_005922.4

p.K1356*

c.4066A>T

1 paper

NM_005922.4

p.G1350Splc

c.4049-11A>G

1 paper

NM_005922.4

p.E1373_I1374Splc

c.4119+38G>A

1 paper

NM_005922.4

p.D1380N

c.4138G>A

1 paper

NM_005922.4

p.D1389N

c.4165G>A

1 paper

NM_005922.4

p.E1390*

c.4168G>T

1 paper

NM_005922.4

p.N1401T

c.4202A>C