Varaico: Literature-Extracted Genetic Variants

MAP3K4

247 papers

RefSeq Summary

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific M...

Pfam Domains

MEKK4_Naa 51–1269UCSCMEKK4 N-terminal

MEKK4_Naa 1169–1215UCSCMEKK4 N-terminal

Pkinaseaa 1343–1601UCSCProtein kinase domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 4

HGNC Previous Symbol

MEKK4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005922.4

p.R1412_E1413Splc

c.4236+156T>G

Surrounding Variants

1 paper

NM_005922.4

p.R1404W

c.4210C>T

1 paper

NM_005922.4

p.N1401T

c.4202A>C

1 paper

NM_005922.4

p.E1390*

c.4168G>T

1 paper

NM_005922.4

p.D1389N

c.4165G>A

1 paper

NM_005922.4

p.D1380N

c.4138G>A

2 papers

NM_005922.4

p.M1415I

c.4245G>A

2 papers

NM_005922.4

p.M1415I

c.4245G>C

2 papers

NM_005922.4

p.M1415I

c.4245G>T

1 paper

NM_005922.4

p.C1422C

c.4266C>T

1 paper

NM_005922.4

p.E1429K

c.4285G>A

1 paper

NM_005922.4

p.R1441G

c.4321A>G

1 paper

NM_005922.4

p.S1444*

c.4331C>A