Varaico: Literature-Extracted Genetic Variants

MAP3K5

275 papers

RefSeq Summary

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/...

Pfam Domains

DRHyd-ASKaa 115–150UCSCDeoxyribohydrolase (DRHyd) domain of the ASK signalosome

MAP3K_TRAF_bdaa 165–545UCSCMAP3K TRAFs-binding domain

ASK_PHaa 555–654UCSCASK kinase PH domain

Pkinaseaa 682–938UCSCProtein kinase domain

HisK-N-likeaa 1042–1173UCSCHisK-N-like globin domain of the ASK signalosome

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 5

HGNC Previous Symbol

MEKK5

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005923.4

p.G790E

c.2369G>A

Surrounding Variants

1 paper

NM_005923.4

p.K792R

c.2375A>G

1 paper

NM_005923.4

p.L794F

c.2380C>T

1 paper

NM_005923.4

p.L794L

c.2382C>T

1 paper

NM_005923.4

p.K785R

c.2354A>G

1 paper

NM_005923.4

p.F782L

c.2346T>G

1 paper

NM_005923.4

p.F782L

c.2346T>A

1 paper

NM_005923.4

p.F782L

c.2344T>C

3 papers

NM_005923.4

p.I780F

c.2338A>T

1 paper

NM_005923.4

p.R802W

c.2404C>T

1 paper

NM_005923.4

p.D775delFs

c.2323_2324delTC

1 paper

NM_005923.4

p.G771A

c.2312G>C

1 paper

NM_005923.4

p.V757V

c.2271C>T