Varaico: Literature-Extracted Genetic Variants

MAP3K5

275 papers

RefSeq Summary

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/...

Pfam Domains

DRHyd-ASKaa 115–150UCSCDeoxyribohydrolase (DRHyd) domain of the ASK signalosome

MAP3K_TRAF_bdaa 165–545UCSCMAP3K TRAFs-binding domain

ASK_PHaa 555–654UCSCASK kinase PH domain

Pkinaseaa 682–938UCSCProtein kinase domain

HisK-N-likeaa 1042–1173UCSCHisK-N-like globin domain of the ASK signalosome

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 5

HGNC Previous Symbol

MEKK5

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_005923.4

p.K709R

c.2126A>G

Surrounding Variants

2 papers

NM_005923.4

p.K709M

c.2126A>T

1 paper

NM_005923.4

p.E710K

c.2128G>A

1 paper

NM_005923.4

p.E710G

c.2129A>G

1 paper

NM_005923.4

p.I711I

c.2133C>T

1 paper

NM_005923.4

p.R705I

c.2114G>T

1 paper

NM_005923.4

p.Q703*

c.2107C>T

1 paper

NM_005923.4

p.R698W

c.2092C>T

1 paper

NM_005923.4

p.G697S

c.2089G>A

1 paper

NM_005923.4

p.G692W

c.2074G>T

1 paper

NM_005923.4

p.T690I

c.2069C>T

1 paper

NM_005923.4

p.G689C

c.2065G>T

1 paper

NM_005923.4

p.G687E

c.2060G>A