Varaico: Literature-Extracted Genetic Variants

MAP3K5

275 papers

RefSeq Summary

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/...

Pfam Domains

DRHyd-ASKaa 115–150UCSCDeoxyribohydrolase (DRHyd) domain of the ASK signalosome

MAP3K_TRAF_bdaa 165–545UCSCMAP3K TRAFs-binding domain

ASK_PHaa 555–654UCSCASK kinase PH domain

Pkinaseaa 682–938UCSCProtein kinase domain

HisK-N-likeaa 1042–1173UCSCHisK-N-like globin domain of the ASK signalosome

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 5

HGNC Previous Symbol

MEKK5

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_005923.4

p.A76A

c.228C>T

Surrounding Variants

1 paper

NM_005923.4

p.G81G

c.243C>T

1 paper

NM_005923.4

p.T71P

c.211A>C

1 paper

NM_005923.4

p.G85R

c.253G>C

1 paper

NM_005923.4

p.R89L

c.266G>T

1 paper

NM_005923.4

p.R90R

c.268C>A

1 paper

NM_005923.4

p.P63S

c.187C>T

1 paper

NM_005923.4

p.N56_A62ins2

c.168_185dup18

1 paper

NM_005923.4

p.N56_A62del0

c.168_185del18

1 paper

NM_005923.4

p.T91A

c.271A>G

1 paper

NM_005923.4

p.A61delFs

c.183delA

1 paper

NM_005923.4

p.T91I

c.272C>T

1 paper

NM_005923.4

p.S59S

c.177C>T