Varaico: Literature-Extracted Genetic Variants

MAP3K5

275 papers

RefSeq Summary

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/...

Pfam Domains

DRHyd-ASKaa 115–150UCSCDeoxyribohydrolase (DRHyd) domain of the ASK signalosome

MAP3K_TRAF_bdaa 165–545UCSCMAP3K TRAFs-binding domain

ASK_PHaa 555–654UCSCASK kinase PH domain

Pkinaseaa 682–938UCSCProtein kinase domain

HisK-N-likeaa 1042–1173UCSCHisK-N-like globin domain of the ASK signalosome

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 5

HGNC Previous Symbol

MEKK5

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005923.4

p.P25T

c.73C>A

Surrounding Variants

1 paper

NM_005923.4

p.E26*

c.76G>T

1 paper

NM_005923.4

p.T23T

c.69C>T

1 paper

NM_005923.4

p.T23T

c.69C>A

1 paper

NM_005923.4

p.G20D

c.59G>A

1 paper

NM_005923.4

p.A17delFs

c.51delG

2 papers

NM_005923.4

p.R31R

c.93G>A

1 paper

NM_005923.4

p.P18H

c.53C>A

1 paper

NM_005923.4

p.F16L

c.48C>G

1 paper

NM_005923.4

p.F16L

c.48C>A

1 paper

NM_005923.4

p.F16L

c.46T>C

1 paper

NM_005923.4

p.A35E

c.104C>A

1 paper

NM_005923.4

p.V38M

c.112G>A