Varaico: Literature-Extracted Genetic Variants

MAP4K3

104 papers

RefSeq Summary

This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced ...

Pfam Domains

Pkinaseaa 1–210UCSCProtein kinase domain

Pkinaseaa 16–273UCSCProtein kinase domain

CNHaa 571–863UCSCCNH domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase kinase 3

HGNC Previous Symbol

RAB8IPL1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003618.4

p.R168W

c.502C>T

Surrounding Variants

2 papers

NM_003618.4

p.S170A

c.508T>G

1 paper

NM_003618.4

p.S170F

c.509C>T

1 paper

NM_003618.4

p.I172V

c.514A>G

2 papers

NM_003618.4

p.A163G

c.488C>G

1 paper

NM_003618.4

p.G156V

c.467G>T

1 paper

NM_003618.4

p.G156R

c.466G>C

1 paper

NM_003618.4

p.G156R

c.466G>A

1 paper

NM_003618.4

p.A153T

c.457G>A

1 paper

NM_003618.4

p.T145M

c.434C>T

1 paper

NM_003618.4

p.L144F

c.432A>T

1 paper

NM_003618.4

p.L144F

c.432A>C

1 paper

NM_003618.4

p.K132R

c.395A>G