Varaico: Literature-Extracted Genetic Variants

Gene:MAP4K4
Variant:p.D20fs

MAP4K4

220 papers

RefSeq Summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is fou...

Pfam Domains

Pkinaseaa 25–289UCSCProtein kinase domain
CNHaa 1080–1354UCSCCNH domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase kinase 4

HGNC Alias Symbols

HGK; NIK; FLH21957

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_001395002.1
p.D20fs
c.58_59fs
Surrounding Variants
1 paper
NM_001395002.1
p.P21R
c.62C>G
1 paper
NM_001395002.1
p.P21P
c.63T>G
1 paper
NM_001395002.1
p.A22insFs
c.64_65insG
1 paper
NM_001395002.1
p.A22insFs
c.64_65insC
1 paper
NM_001395002.1
p.A22insFs
c.64_65insT
2 papers
NM_001395002.1
p.A22insFs
c.65_66insT
1 paper
NM_001395002.1
p.G23insFs
c.68_69insA
1 paper
NM_001395002.1
p.G23insFs
c.68_69insT
1 paper
NM_001395002.1
p.I24_F25delFs
c.72_73delTT
1 paper
NM_001395002.1
p.E26insFs
c.77_78insT
1 paper
NM_001395002.1
p.L27V
c.79C>G
1 paper
NM_001395002.1
p.E29G
c.86A>G
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