Varaico: Literature-Extracted Genetic Variants

Gene:MAP4K4
Variant:p.Y76F

MAP4K4

220 papers

RefSeq Summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is fou...

Pfam Domains

Pkinaseaa 25–289UCSCProtein kinase domain
CNHaa 1080–1354UCSCCNH domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase kinase 4

HGNC Alias Symbols

HGK; NIK; FLH21957

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_001395002.1
p.Y76F
c.227A>T
Surrounding Variants
1 paper
NM_001395002.1
p.S77_H78insT
c.229_233ins3
1 paper
NM_001395002.1
p.K74N
c.222G>C
1 paper
NM_001395002.1
p.K74N
c.222G>T
1 paper
NM_001395002.1
p.M72_L73del2
c.214_218del6
1 paper
NM_001395002.1
p.L68_E69insA
c.202_206ins3
1 paper
NM_001395002.1
p.E65_I66insT
c.193_197ins3
2 papers
NM_001395002.1
p.E64_E65insT
c.190_194ins3
1 paper
NM_001395002.1
p.K91E
c.271A>G
1 paper
NM_001395002.1
p.L103F
c.307C>T
1 paper
NM_001395002.1
p.L103L
c.309T>A
1 paper
NM_001395002.1
p.F107I
c.319T>A
2 papers
NM_001395002.1
p.A110T
c.328G>A
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