mitogen-activated protein kinase 10

PRKM10

JNK3

p493F12

p54bSAPK

Mitogen-activated protein kinase 10

MAP kinase p49 3F12

Stress-activated protein kinase 1b

Stress-activated protein kinase JNK3

c-Jun N-terminal kinase 3

MAP kinase 10

MAPK 10

SAPK1b

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017].

Varaico: Literature-Extracted Genetic Variants

MAPK10

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol