membrane associated ring-CH-type finger 1

MARCH1

FLJ20668

MARCH-I

RNF171

membrane-associated ring finger (C3HC4) 1

membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase MARCHF1

Membrane-associated RING finger protein 1

Membrane-associated RING-CH protein I

RING finger protein 171

RING-type E3 ubiquitin transferase MARCHF1

MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010].

Varaico: Literature-Extracted Genetic Variants

MARCHF1

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol