membrane associated ring-CH-type finger 2

MARCH2

HSPC240

MARCH-II

RNF172

membrane-associated ring finger (C3HC4) 2

membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase MARCHF2

ring finger protein 172

Membrane-associated RING finger protein 2

Membrane-associated RING-CH protein II

RING finger protein 172

RING-type E3 ubiquitin transferase MARCHF2

MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010].

Varaico: Literature-Extracted Genetic Variants

MARCHF2

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol