Varaico: Literature-Extracted Genetic Variants

MCM4

185 papers

RefSeq Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein...

Pfam Domains

MCM_Naa 163–264UCSCMCM N-terminal domain

MCM_OBaa 270–398UCSCMCM OB domain

MCMaa 445–670UCSCMCM P-loop domain

MCM_lidaa 685–769UCSCMCM AAA-lid domain

WHD_MCM4aa 792–862UCSCMCM4, winged helix domain

Gene Aliases

HGNC Name

minichromosome maintenance complex component 4

HGNC Previous Symbol

CDC21

Papers

RefSeq ID

Protein change

DNA change

1–12 of 155 variants

7 papers

NM_182746.3

p.L650M

c.1948T>A

4 papers

NM_182746.3

p.M1insFs

c.1_2insG

4 papers

NM_182746.3

p.I283T

c.848T>C

4 papers

NM_182746.3

p.F346I

c.1036T>A

4 papers

NM_182746.3

p.G364R

c.1090G>A

4 papers

NM_182746.3

p.G364R

c.1090G>C

3 papers

NM_182746.3

p.P24Splc

c.71-2A>G

3 papers

NM_182746.3

p.Q74*

c.220C>T

3 papers

NM_182746.3

p.K163E

c.487A>G

3 papers

NM_182746.3

p.R610H

c.1829G>A

2 papers

NM_182746.3

p.R248H

c.743G>A

2 papers

NM_182746.3

p.N270S

c.809A>G