Varaico: Literature-Extracted Genetic Variants

MCM4

185 papers

RefSeq Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein...

Pfam Domains

MCM_Naa 163–264UCSCMCM N-terminal domain

MCM_OBaa 270–398UCSCMCM OB domain

MCMaa 445–670UCSCMCM P-loop domain

MCM_lidaa 685–769UCSCMCM AAA-lid domain

WHD_MCM4aa 792–862UCSCMCM4, winged helix domain

Gene Aliases

HGNC Name

minichromosome maintenance complex component 4

HGNC Previous Symbol

CDC21

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_182746.3

p.M1L

c.1A>T

Surrounding Variants

4 papers

NM_182746.3

p.M1insFs

c.1_2insG

1 paper

NM_182746.3

p.M1delFs

c.2delT

1 paper

NM_182746.3

p.P4P

c.12G>C

1 paper

NM_182746.3

p.A5A

c.15G>A

1 paper

NM_182746.3

p.R10P

c.29G>C

1 paper

NM_182746.3

p.G12S

c.34G>A

1 paper

NM_182746.3

p.G12C

c.34G>T

1 paper

NM_182746.3

p.P24insFs

c.70_71insG

3 papers

NM_182746.3

p.P24Splc

c.71-2A>G

1 paper

NM_182746.3

p.S26N

c.77G>A

1 paper

NM_182746.3

p.A29T

c.85G>A

1 paper

NM_182746.3

p.P33S

c.97C>T