Varaico: Literature-Extracted Genetic Variants

MCM4

185 papers

RefSeq Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein...

Pfam Domains

MCM_Naa 163–264UCSCMCM N-terminal domain

MCM_OBaa 270–398UCSCMCM OB domain

MCMaa 445–670UCSCMCM P-loop domain

MCM_lidaa 685–769UCSCMCM AAA-lid domain

WHD_MCM4aa 792–862UCSCMCM4, winged helix domain

Gene Aliases

HGNC Name

minichromosome maintenance complex component 4

HGNC Previous Symbol

CDC21

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_182746.3

p.P24Splc

c.71-2A>G

Surrounding Variants

1 paper

NM_182746.3

p.S26N

c.77G>A

1 paper

NM_182746.3

p.A29T

c.85G>A

1 paper

NM_182746.3

p.P33S

c.97C>T

1 paper

NM_182746.3

p.P33P

c.99C>T

1 paper

NM_182746.3

p.V57E

c.170T>A

1 paper

NM_182746.3

p.P62S

c.184C>T

1 paper

NM_182746.3

p.A64T

c.190G>A

1 paper

NM_182746.3

p.D66N

c.196G>A

1 paper

NM_182746.3

p.V67L

c.199G>C

1 paper

NM_182746.3

p.V67L

c.199G>T

1 paper

NM_182746.3

p.S70_S71insG

c.208_212ins3

3 papers

NM_182746.3

p.Q74*

c.220C>T